Deferiprone reduces hemosiderin deposits in the brain of a patient with superficial siderosis.
نویسندگان
چکیده
A man with superficial siderosis showed improvement in symptoms and reduction in hemosiderin by MR imaging following treatment with deferiprone, a lipid-soluble iron chelator.
منابع مشابه
Pilot safety trial of deferiprone in 10 subjects with superficial siderosis.
BACKGROUND AND PURPOSE Superficial siderosis is a neurodegenerative disease caused by toxic accumulation of hemosiderin on the surface of the brain and spinal cord for which there is no known effective treatment. METHODS Oral deferiprone, a lipid-soluble iron chelator with ability to cross the blood-brain barrier, at a dose of 30 mg/kg per day was tested for safety in an open pilot study in 1...
متن کاملUpdate on a patient with superficial siderosis on deferiprone.
Deferiprone Superficial siderosis (SS) is a neurodegenerative condition caused by hemosiderin deposition on the surface of the brain, cranial nerves, and spinal cord. SS is an exceptionally rare condition characterized by a triad of hearing loss, ataxia, and myelopathy. The most common etiologies that lead to SS are trauma, previous surgical procedures, dural tears, and tumors of the central ne...
متن کاملA patient with superficial siderosis, intraspinal cyst, low-pressure headache and low-lying cord.
Superficial siderosis is a rare condition caused by deposition of hemosiderin in the central nervous system. In recent years, it has been used to identify dural defects connecting the intrathecal space with the intraspinal fluid-filled collection seen in patients with superficial siderosis. However rare reports describe the association of low-lying cord in superficial siderosis patients. We pre...
متن کاملTeaching neuroImages: MRI changes in superficial siderosis.
A 41-year-old woman presented with 2 months of dysarthria. Her history included 6 years of unsteadiness resulting in multiple falls and 10 years of intermittent urinary incontinence. She had a history of significant trauma including having been knocked over by a horse and being involved in 2 car accidents, 1 resulting in loss of consciousness and amnesia. On examination, she had finger-nose dys...
متن کاملSuperficial siderosis of the CNS: MR diagnosis and clinical findings.
PURPOSE To report the clinical and neuroradiologic findings of superficial siderosis of the CNS, due to chronic subarachnoid bleeding of unknown origin. MATERIALS AND METHODS We observed seven cases. The main clinical manifestations were progressive deafness and ataxia. Four patients had had previous cranial or cervical trauma, with root avulsion in two, many years before onset of deafness an...
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ورودعنوان ژورنال:
- AJNR. American journal of neuroradiology
دوره 32 1 شماره
صفحات -
تاریخ انتشار 2011